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1

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

Foerster, Philippe, Daclin, Marie, Asm, Shihavuddin, Faucourt, Marion, Boletta, Alessandra, Genovesio, Auguste, Spassky, Nathalie

Journal:

Development (The Company of Biologists)

Year:

2017

Language:

english

File:

PDF, 31.95 MB

english, 2017

2

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

Drusian, Luca, Boletta, Alessandra

Journal:

Molecular & Cellular Oncology

Year:

2019

Language:

english

File:

PDF, 1.12 MB

english, 2019

3

Role of polycystins in renal tubulogenesis

Alessandra Boletta, Gregory G Germino

Journal:

Trends in Cell Biology

Year:

2003

Language:

english

File:

PDF, 4.14 MB

english, 2003

4

Defective metabolism in polycystic kidney disease: potential for therapy and open questions

Rowe, I., Boletta, A.

Journal:

Nephrology Dialysis Transplantation

Year:

2014

Language:

english

File:

PDF, 335 KB

english, 2014

5

Metabolism and mitochondria in polycystic kidney disease research and therapy

Padovano, Valeria, Podrini, Christine, Boletta, Alessandra, Caplan, Michael J.

Journal:

Nature Reviews Nephrology (formerly Nature Clinical Practice Nephrology)

Year:

2018

Language:

english

File:

PDF, 2.05 MB

english, 2018

6

[IEEE 2019 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB) - Siena, Italy (2019.7.9-2019.7.11)] 2019 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB) - In SILICO Simulations Predict a Causative Link Between Increased Glycolysis and Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease

Pagliarini, Roberto, Boletta, Alessandra

Year:

2019

Language:

english

File:

PDF, 1.92 MB

english, 2019

7

Prospects for mTOR Inhibitor Use in Patients with Polycystic Kidney Disease and Hamartomatous Diseases

Torres, V. E., Boletta, A., Chapman, A., Gattone, V., Pei, Y., Qian, Q., Wallace, D. P., Weimbs, T., Wuthrich, R. P.

Journal:

Clinical Journal of the American Society of Nephrology

Year:

2010

Language:

english

File:

PDF, 436 KB

english, 2010

8

10.1038/35050128

Guggino, William B., Germino, Gregory G., Hanaoka, Kazushige, Qian, Feng, Boletta, Alessandra, Bhunia, Anil K., Piontek, Klaus, Tsiokas, Leonidas, Sukhatme, Vikas P.

Journal:

Year:

2000

Language:

english

File:

PDF, 307 KB

english, 2000

9

Polycystin-1 Is Required for Stereocilia Structure But Not for Mechanotransduction in Inner Ear Hair Cells

Steigelman, K. A., Lelli, A., Wu, X., Gao, J., Lin, S., Piontek, K., Wodarczyk, C., Boletta, A., Kim, H., Qian, F., Germino, G., Geleoc, G. S. G., Holt, J. R., Zuo, J.

Journal:

Journal of Neuroscience

Year:

2011

Language:

english

File:

PDF, 2.49 MB

english, 2011

10

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

Nigro, Elisa, Castelli, Maddalena, Boletta, Alessandra

Journal:

Year:

2015

Language:

english

File:

PDF, 1.44 MB

english, 2015

11

Glomerular filtration is required for transfection of proximal tubular cells in the rat kidney following injection of DNA complexes into the renal artery

Bragonzi, A, Cortese, M, Cantù, L, Boletta, A, Chiossone, I, Soria, M R, Monaco, L, Foglieni, C

Journal:

Year:

2000

Language:

english

File:

PDF, 261 KB

english, 2000

12

Nonviral Gene Delivery to the Rat Kidney with Polyethylenimine

Boletta, Alessandra, Benigni, Ariela, Lutz, Jens, Remuzzi, Giuseppe, Soria, Marco R., Monaco, Lucia

Journal:

Human Gene Therapy

Year:

1997

Language:

english

File:

PDF, 8.15 MB

english, 1997

13

Defects of glucose metabolism in polycystic kidney disease: first studies and future perspectives

Rowe, Isaline, Chiaravalli, Marco, Boletta, Alessandra

Journal:

Giornale di Tecniche Nefrologiche e Dialitiche

Year:

2013

File:

PDF, 658 KB

2013

14

Increased mitochondrial fragmentation in polycystic kidney disease acts as a modifier of disease progression

Cassina, Laura, Chiaravalli, Marco, Boletta, Alessandra

Journal:

The FASEB Journal

Year:

2020

File:

PDF, 3.79 MB

2020

15

Polycystin-1 Induces Cell Migration by Regulating Phosphatidylinositol 3-kinase-dependent Cytoskeletal Rearrangements and GSK3beta-dependent Cell Cell Mechanical Adhesion

Boca, M., D'Amato, L., Distefano, G., Polishchuk, R. S., Germino, G. G., Boletta, A.

Journal:

Molecular Biology of the Cell

Year:

2007

Language:

english

File:

PDF, 1.92 MB

english, 2007

16

Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo: Role in Polycystic Kidney Disease

Kurbegovic, A., Kim, H., Xu, H., Yu, S., Cruanes, J., Maser, R. L., Boletta, A., Trudel, M., Qian, F.

Journal:

Molecular and Cellular Biology

Year:

2014

Language:

english

File:

PDF, 3.13 MB

english, 2014

17

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

Kim, Hyunho, Xu, Hangxue, Yao, Qin, Li, Weizhe, Huang, Qiong, Outeda, Patricia, Cebotaru, Valeriu, Chiaravalli, Marco, Boletta, Alessandra, Piontek, Klaus, Germino, Gregory G., Weinman, Edward J., Wat

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 3.42 MB

english, 2014

18

Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response Signaling

Airik, R., Slaats, G. G., Guo, Z., Weiss, A.-C., Khan, N., Ghosh, A., Hurd, T. W., Bekker-Jensen, S., Schroder, J. M., Elledge, S. J., Andersen, J. S., Kispert, A., Castelli, M., Boletta, A., Giles, R

Journal:

Journal of the American Society of Nephrology

Year:

2014

Language:

english

File:

PDF, 3.38 MB

english, 2014

19

2-Deoxy-D-Glucose Ameliorates PKD Progression

Chiaravalli, M., Rowe, I., Mannella, V., Quilici, G., Canu, T., Bianchi, V., Gurgone, A., Antunes, S., D'Adamo, P., Esposito, A., Musco, G., Boletta, A.

Journal:

Journal of the American Society of Nephrology

Year:

2015

Language:

english

File:

PDF, 1.77 MB

english, 2015

20

Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs

Bragonzi, A, Boletta, A, Biffi, A, Muggia, A, Sersale, G, Cheng, S H, Bordignon, C, Assael, B M, Conese, M

Journal:

Year:

1999

Language:

english

File:

PDF, 314 KB

english, 1999

21

Slowing Polycystic Kidney Disease by Fasting

Journal:

Journal of the American Society of Nephrology

Year:

2015

Language:

english

File:

PDF, 441 KB

english, 2015

22

Defective glycolysis and the use of 2-deoxy-d-glucose in polycystic kidney disease: from animal models to humans

Magistroni, Riccardo, Boletta, Alessandra

Journal:

Journal of Nephrology

Year:

2017

Language:

english

File:

PDF, 883 KB

english, 2017

23

PKD1 Induces p21waf1 and Regulation of the Cell Cycle via Direct Activation of the JAK-STAT Signaling Pathway in a Process Requiring PKD2

Anil Kumar Bhunia, Klaus Piontek, Alessandra Boletta, Lijuan Liu, Feng Qian, Pei-Ning Xu, F.Joseph Germino, Gregory G Germino

Journal:

Year:

2002

Language:

english

File:

PDF, 681 KB

english, 2002

24

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

Pema, Monika, Drusian, Luca, Chiaravalli, Marco, Castelli, Maddalena, Yao, Qin, Ricciardi, Sara, Somlo, Stefan, Qian, Feng, Biffo, Stefano, Boletta, Alessandra

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 2.51 MB

english, 2016

25

Metabolic reprogramming and the role of mitochondria in polycystic kidney disease

Podrini, Christine, Cassina, Laura, Boletta, Alessandra

Journal:

Cellular Signalling

Year:

2020

File:

PDF, 838 KB

2020

26

Assessing deforestation in the Argentine Chaco

Pedro E. Boletta, Andrés C. Ravelo, Ana M. Planchuelo, Mariano Grilli

Journal:

Forest Ecology and Management

Year:

2006

Language:

english

File:

PDF, 2.10 MB

english, 2006

27

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

Drusian, Luca, Boletta, Alessandra

Journal:

Molecular & Cellular Oncology

Year:

2019

File:

PDF, 1.12 MB

2019

28

Polycystin-1 Negatively Regulates Polycystin-2 Expression via the Aggresome/Autophagosome Pathway

Cebotaru, Valeriu, Cebotaru, Liudmila, Kim, Hyunho, Chiaravalli, Marco, Boletta, Alessandra, Qian, Feng, Guggino, William B.

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 2.40 MB

english, 2014

29

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

Distefano, G., Boca, M., Rowe, I., Wodarczyk, C., Ma, L., Piontek, K. B., Germino, G. G., Pandolfi, P. P., Boletta, A.

Journal:

Molecular and Cellular Biology

Year:

2009

Language:

english

File:

PDF, 2.13 MB

english, 2009

30

A Regulatory Role of Polycystin-1 on Cystic Fibrosis Transmembrane Conductance Regulator Plasma Membrane Expression

Ikeda, Masahiro, Fong, Peying, Cheng, Jie, Boletta, Alessandra, Qian, Feng, Zhang, Xue-Mei, Cai, Hui, Germino, Gregory G., Guggino, William B.

Journal:

Cellular Physiology and Biochemistry

Year:

2006

Language:

english

File:

PDF, 853 KB

english, 2006

31

Phosphoinositide 3-Kinase-C2 Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation

Franco, I., Margaria, J. P., De Santis, M. C., Ranghino, A., Monteyne, D., Chiaravalli, M., Pema, M., Campa, C. C., Ratto, E., Gulluni, F., Perez-Morga, D., Somlo, S., Merlo, G. R., Boletta, A., Hirsc

Journal:

Journal of the American Society of Nephrology

Year:

2015

Language:

english

File:

PDF, 1.86 MB

english, 2015

32

Polycystin-1, the Gene Product of PKD1, Induces Resistance to Apoptosis and Spontaneous Tubulogenesis in MDCK Cells

Alessandra Boletta, Feng Qian, Luiz F. Onuchic, Anil K. Bhunia, Bunyong Phakdeekitcharoen, Kazushige Hanaoka, William Guggino, Lucia Monaco, Gregory G. Germino

Journal:

Year:

2000

Language:

english

File:

PDF, 458 KB

english, 2000

33

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

Rowe, Isaline, Chiaravalli, Marco, Mannella, Valeria, Ulisse, Valeria, Quilici, Giacomo, Pema, Monika, Song, Xuewen W, Xu, Hangxue, Mari, Silvia, Qian, Feng, Pei, York, Musco, Giovanna, Boletta, Aless

Journal:

Nature Medicine

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

34

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures

Rowe, Isaline, Chiaravalli, Marco, Piontek, Klaus B., Germino, Gregory G., Boletta, Alessandra

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 1.84 MB

english, 2014

35

The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets

Iaconis, Daniela, Monti, Maria, Renda, Mario, van Koppen, Arianne, Tammaro, Roberta, Chiaravalli, Marco, Cozzolino, Flora, Pignata, Paola, Crina, Claudia, Pucci, Piero, Boletta, Alessandra, Belcastro,

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.94 MB

english, 2017

36

Emerging evidence of a link between the polycystins and the mTOR pathways

Alessandra Boletta

Journal:

Year:

2009

Language:

english

File:

PDF, 1.09 MB

english, 2009

37

A Novel Mouse Model Reveals that Polycystin-1 Deficiency in Ependyma and Choroid Plexus Results in Dysfunctional Cilia and Hydrocephalus

Wodarczyk, Claas, Rowe, Isaline, Chiaravalli, Marco, Pema, Monika, Qian, Feng, Boletta, Alessandra, Gonzalez, Cayetano

Journal:

Year:

2009

Language:

english

File:

PDF, 853 KB

english, 2009

38

Obituary.

Rowe, Isaline, Chiaravalli, Marco, Piontek, Klaus B., Germino, Gregory G., Boletta, Alessandra

Journal:

Year:

1905

Language:

english

File:

PDF, 389 KB

english, 1905

39

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations

Qian, F., Boletta, A., Bhunia, A. K., Xu, H., Liu, L., Ahrabi, A. K., Watnick, T. J., Zhou, F., Germino, G. G.

Journal:

Proceedings of the National Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 553 KB

english, 2002

40

Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8

Billot, Katy, Coquil, Charlène, Villiers, Benoit, Josselin-Foll, Béatrice, Desban, Nathalie, Delehouzé, Claire, Oumata, Nassima, Le Meur, Yannick, Boletta, Alessandra, Weimbs, Thomas, Grosch, Melanie,

Journal:

American journal of physiology. Renal physiology

Year:

2018

Language:

english

File:

PDF, 2.49 MB

english, 2018

41

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness

Nigro, Elisa Agnese, Distefano, Gianfranco, Chiaravalli, Marco, Matafora, Vittoria, Castelli, Maddalena, Pesenti Gritti, Angela, Bachi, Angela, Boletta, Alessandra

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 5.69 MB

english, 2019

42

48. Barriers involved in gene transfer to the lungs with non-viral vectors

A. Bragonzi, A. Boletta, C. Bordignon, B.M. Assael, M. Conese

Journal:

The Netherlands Journal of Medicine

Year:

1999

Language:

english

File:

PDF, 15 KB

english, 1999

43

Biochemical characterization of bona fide polycystin-1 in vitro and in vivo

Alessandra Boletta, Feng Qian, Luiz F. Onuchic, Alessandra Bragonzi, Marina Cortese, Peter M. Deen, Pierre J. Courtoy, Marco R. Soria, Olivier Devuyst, Lucia Monaco, Gregory G. Germino

Journal:

American Journal of Kidney Diseases

Year:

2001

Language:

english

File:

PDF, 317 KB

english, 2001

44

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium

Ohata, S., Herranz-Perez, V., Nakatani, J., Boletta, A., Garcia-Verdugo, J. M., Alvarez-Buylla, A.

Journal:

Journal of Neuroscience

Year:

2015

Language:

english

File:

PDF, 12.91 MB

english, 2015

45

The polycystins are modulated by cellular oxygen sensing pathways and regulate mitochondrial function

Padovano, V., Kuo, I. Y., Stavola, L. K., Aerni, H. R., Flaherty, B. J., Chapin, H. C., Ma, M., Somlo, S., Boletta, A., Ehrlich, B. E., Rinehart, J., Caplan, M. J.

Journal:

Molecular Biology of the Cell

Year:

2016

Language:

english

File:

PDF, 1.09 MB

english, 2016

46

Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma

Clerici, Sara, Boletta, Alessandra

Journal:

Year:

2020

File:

PDF, 1.13 MB

2020

47

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis

Castelli, Maddalena, Boca, Manila, Chiaravalli, Marco, Ramalingam, Harini, Rowe, Isaline, Distefano, Gianfranco, Carroll, Thomas, Boletta, Alessandra

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 2.23 MB

english, 2013

48

Il Registro Italiano del Rene Policistico Autosomico Dominante

Carrera, P., Palmieri, L., Caruso, F., Lodi, D., Rigo, F., Furci, L., Granito, M., Damiano, F., Iatrino, R., Boletta, A., Ferrari, M., Aguiari, G., Magistroni, R.

Journal:

Giornale di Tecniche Nefrologiche e Dialitiche

Year:

2010

File:

PDF, 204 KB

2010

49

Metabolic reprogramming in polycystic kidney disease explained by super-enhancers and CDK7: new therapeutic targets?

Cassina, Laura, Boletta, Alessandra

Journal:

Nature Metabolism

Year:

2020

File:

PDF, 1.06 MB

2020

50

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells

de Stephanis, Lucia, Bonon, Anna, Varani, Katia, Lanza, Giovanni, Gafà, Roberta, Pinton, Paolo, Pema, Monika, Somlo, Stefan, Boletta, Alessandra, Aguiari, Gianluca

Journal:

Clinical and Experimental Nephrology

Year:

2017

Language:

english

File:

PDF, 1.85 MB

english, 2017

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